IDENTIFICATION OF NOVEL MUTATIONS IN CHINESE HANS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disease with an incidence of 1 in 400 to 1000.The disease is genetically heterogeneous, with two genes identified: PKD1 (16p13.3) and PKD2 (4q21).Molecular diagnosis of the disease in at-risk individuals is complicated due to the structural c

IntroductionElectrical impedance tomography (EIT) is an emerging clinical tool for monitoring ventilation distribution in mechanically ventilated patients, for which many image reconstruction algorithms have been suggested.We propose an experimental framework to assess such algorithms with respect to their ability to correctly represent well-define